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#Catalepsy vs cataplexy trial#
(2) Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial.(1) The anticonvulsant properties of the endogenous excitatory amino acid antagonist, kynurenic acid (KYA), were studied in prepubescent and adult rats using the amygdaloid kindling model of epilepsy.(n.) The "falling sickness," so called because the patient falls suddenly to the ground a disease characterized by paroxysms (or fits) occurring at interval and attended by sudden loss of consciousness, and convulsive motions of the muscles.(20) Catalepsy, measured by the duration of loss of righting reflex (DLRR) in catatonic animals, was induced by larger doses of both ketamine and morphine and in each case was reduced by a larger dose of naloxone.(19) Striatal dopamine (DA) stores were only minimally depleted at the time of catalepsy potentiation.(18) MK-801 also potentiated the anticataleptic effect of scopolamine and bromocriptine against haloperidol-induced catalepsy.
#Catalepsy vs cataplexy series#
(17) A series of aryl-piperazine analogues of buspirone and other 5-hydroxytryptaminergic agonists were tested for their ability to reverse haloperidol induced catalepsy.(16) When the catalepsy score was almost maximal (60 s, measured by the bar-test), the rats were handled, exposed to cold (3 degrees C) or immobilized.(15) In a second experiment, thioridazine, dopamine, norepinephrine, serotonin and their metabolites were assayed in the brain of the rat after acute administration of the enantiomers of thioridazine and the assessment of catalepsy.(14) The action of opiates leading to an inhibition of flexor alpha-motoneurones may contribute to akinesia and catalepsy, and opioid-induced muscular rigidity.(13) The results, together with a literature survey on the anticholinergic effects on neuroleptic-induced catalepsy and inhibition of avoidance behavior, are related to biochemical findings and clinical effects.
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